DISCUSSION: THE NEW FOOD AND AGRICULTURE BILL - WHERE IS IT HEADED? POTENTIAL IMPACTS ON SOUTHERN AGRICULTURE

Political Economy,

OBSERVATIONS ON CHANGES IN FACTORS INFLUENCING AGRICULTURAL ECONOMICS AND SOME IMPLICATIONS FOR THE PROFESSION

Teaching/Communication/Extension/Profession,

Oncolytic herpes viruses, chemotherapeutics, and other cancer drugs

Oncolytic viruses are emerging as a potential new way of treating cancers. They are selectively replication-competent viruses that propagate only in actively dividing tumor cells but not in normal cells and, as a result, destroy the tumor cells by consequence of lytic infection. At least six different oncolytic herpes simplex viruses (oHSVs) have undergone clinical trials worldwide to date, and they have demonstrated an excellent safety profile and intimations of efficacy. The first pivotal Phase III trial with an oHSV, talimogene laherparepvec (T-Vec [OncoVex<sup>GM-CSF</sup>]), is almost complete, with extremely positive early results reported. Intuitively, therapeutically beneficial interactions between oHSV and chemotherapeutic and targeted therapeutic drugs would be limited as the virus requires actively dividing cells for maximum replication efficiency and most anticancer agents are cytotoxic or cytostatic. However, combinations of such agents display a range of responses, with antagonistic, additive, or, perhaps most surprisingly, synergistic enhancement of antitumor activity. When synergistic interactions in cancer cell killing are observed, chemotherapy dose reductions that achieve the same overall efficacy may be possible, resulting in a valuable reduction of adverse side effects. Therefore, the combination of an oHSV with “standard-of-care” drugs makes a logical and reasonable approach to improved therapy, and the addition of a targeted oncolytic therapy with “standard-of-care” drugs merits further investigation, both preclinically and in the clinic. Numerous publications report such studies of oncolytic HSV in combination with other drugs, and we review their findings here. Viral interactions with cellular hosts are complex and frequently involve intracellular signaling networks, thus creating diverse opportunities for synergistic or additive combinations with many anticancer drugs. We discuss potential mechanisms that may lead to synergistic interactions

GROUND BEEF: IMPLICATIONS FOR THE SOUTHEASTERN U.S. BEEF INDUSTRY

Livestock Production/Industries,

SPATIAL AND TEMPORAL WATER ALLOCATION IN THE KISSIMMEE RIVER BASIN

Resource /Energy Economics and Policy,

COMPONENTS OF OUTDOOR RECREATIONAL VALUES: KISSIMMEE RIVER BASIN, FLORIDA

Resource /Energy Economics and Policy,

ECONOMIC FEASIBILITY OF USING BRUSH CONTROL TO ENHANCE OFF-SITE WATER YIELD

A feasibility study of brush for off-site water yield was undertaken in 1998 on the North Concho River near San Angelo, Texas. Subsequently, studies were conducted on eight additional Texas watersheds. Economic analysis was based on estimated control costs of the different options compared to the estimated rancher benefits of brush control. Control costs included initial and follow-up treatments required to reduce brush canopy to between 3 and 8%, and maintain it at the reduced level for 10 years. The state cost-share was estimated by subtracting the present value of rancher benefits from the present value of the total cost of the control program. The total cost of additional water was determined by dividing the total state cost-share if all eligible acreage were enrolled by the total added water estimated to result from the brush control program. This procedure resulted in present values of total control costs per acre ranging from $33.75 to$159.45. Rancher benefits, based on the present value of the improved net returns to typical cattle, sheep, goat, and wildlife enterprises, ranged from $8.95 to$52.12 per acre. Present values of the state cost-share per acre ranged from $21.70 to$138.85. The cost of added water estimated for the eight watersheds ranged from $16.41 to$204.05 per acre-foot averaged over each watershed.Resource /Energy Economics and Policy,

Multirole cargo aircraft options and configurations

A future requirements and advanced market evaluation study indicates derivatives of current wide-body aircraft, using 1980 advanced technology, would be economically attractive through 2008, but new dedicated airfreighters incorporating 1990 technology, would offer little or no economic incentive. They would be economically attractive for all payload sizes, however, if RD and T costs could be shared in a joint civil/military arrangement. For the 1994-2008 cargo market, option studies indicate Mach 0.7 propfans would be economically attractive in trip cost, aircraft price and airline ROI. Spanloaders would have an even lower price and higher ROI but would have a relatively high trip cost because of aerodynamic inefficiencies. Dedicated airfreighters using propfans at Mach 0.8 cruise, laminar flow control, or cryofuels, would not provide any great economic benefits. Air cushion landing gear configurations are identified as an option for avoiding runway constraints on airport requirements and/or operational constraints are noted